Article

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen

2025-08-14

Abstract excerpt

The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their importance, the mechanisms governing LAD positioning in human cells remain poorly understood. To this end, we performed a genome-wide imaging-based siRNA screen and identified over 100 genes critical for perinuclear L...

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Literature Corpus work: 83ccbfa7-08bc-5d5d-a46b-78fbb54ad309
DOI: 10.1101/2025.08.13.670143

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