Article

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

2023-11-02

Abstract excerpt

<h4>ABSTRACT</h4> Breast cancer is a heterogeneous disease, and treatment is guided by biomarker profiles representing distinct molecular subtypes. Breast cancer arises from the breast ductal epithelium, and experimental data suggests breast cancer subtypes have different cells of origin within that lineage. The precise cells of origin for each subtype and the transcriptional networks that characterize these tumo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b6540f1-aea4-5cae-9e79-ed514f636195
DOI: 10.1101/2023.10.31.565031

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineagesDOI 10.1101/2023.10.31.565031Read

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineagesSemantic proximity Read

Defining the Regulatory Logic of Breast Cancer Using Single-Cell Epigenetic and Transcriptome ProfilingSemantic proximity Read

Single-cell and spatially resolved analysis uncovers cell heterogeneity of breast cancerSemantic proximity Read

A spatially resolved single cell genomic atlas of the adult human breastSemantic proximity Read

Defining the regulatory logic of breast cancer using single-cell epigenetic and transcriptome profilingSemantic proximity Read

A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cellsSemantic proximity Read

Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutationsSemantic proximity Read

Learning the cellular origins of cancer using single-cell chromatin landscapesSemantic proximity Read

A single cell atlas of the healthy breast tissues reveal clinically relevant clusters of breast epithelial cellsSemantic proximity Read

Single-Cell Transcriptional and Epigenetic Profiles of Male Breast Cancer Nominate Salient Cancer-Specific EnhancersSemantic proximity Read

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustionSemantic proximity Read

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatmentSemantic proximity Read