Article

HP1α depletion and TGFβ activation exert antagonistic effects on 3D genome organization

2026-02-13

Abstract excerpt

The three-dimensional (3D) organization of the human genome plays a critical role in regulating gene expression and is frequently disrupted in cancer. However, how key factors like Heterochromatin Protein 1 alpha (HP1α) and Transforming Growth Factor beta (TGFβ) remodel this architecture to drive tumorigenesis remains poorly understood. We investigated the effects of HP1α knockdown and TGFβ treatment on higher-ord...

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Literature Corpus work: 38920091-9955-5e1b-a890-aa1266906d9e
DOI: 10.64898/2026.02.12.705282

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