Article

Integrative epigenomic profiling by high-speed super-resolution imaging and deep learning reveals chromatin state biomarkers

2025-10-22

Abstract excerpt

<title>Abstract</title> <p> Background Comprehensive profiling of epigenetic states is essential for understanding gene regulation and disease mechanisms. Sequencing-based methods such as ChIP-seq, Hi-C, and RNA-seq provide genome-wide views of histone modifications and 3D genome organization, but lack spatial resolution within single nuclei. Results Here we present an integrative framework that combines high-sp...

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Literature Corpus work: 3d8738d0-1958-5572-a4e5-889afddda1ad
DOI: 10.21203/rs.3.rs-7787625/v1

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