Article

Repertoire-level generation of T-cell epitopes with a large-scale generative transformer

2025-01-14

Abstract excerpt

Single-cell TCR sequencing enables high-resolution analysis of T Cell Receptor (TCR) diversity and clonality, offering valuable insights into immune responses and disease mechanisms. However, identifying cognate epitopes for individual TCRs requires complex and costly functional assays. We address this challenge with EpitopeGen, a large-scale transformer model based on the GPT-2 architecture that generates potenti...

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Literature Corpus work: cdf2add1-3753-5c01-9878-7091232b73d4
DOI: 10.1101/2025.01.13.632824

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