Generative AI-Guided Design of High-Affinity T Cell Receptors

Abstract excerpt

Developing T cell receptors (TCRs) with sufficiently high affinity for tumor antigens (TAs) remains a fundamental challenge in TCR-T immunotherapy. Experimental methods such as affinity maturation and high-throughput screening have enabled the identification of TCRs with enhanced activity. However, their efficiency is often constrained by limited throughput, insufficient coverage, and the generally lower affinitie...

Topics

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• Bayes Theorem
• Computational Biology
• Cross Reactions
• Epitopes, T-Lymphocyte
• Mice
• Peptides
• Receptors, Antigen, T-Cell
• T-Lymphocytes

Identifiers and source

Literature Corpus work

5a2b187f-a142-53d3-b121-f058b94a0433

DOI

10.64898/2026.02.12.705547