Article

Comprehensive epitope mutational scan database enables accurate T cell receptor cross-reactivity prediction

2024-01-25

Abstract excerpt

<h4>ABSTRACT</h4> Predicting T cell receptor (TCR) activation is challenging due to the lack of both unbiased benchmarking datasets and computational methods that are sensitive to small mutations to a peptide. To address these challenges, we curated a comprehensive database, called BATCAVE, encompassing complete single amino acid mutational assays of more than 22,000 TCR-peptide pairs, centered around 25 immunoge...

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Literature Corpus work: e629f557-15c1-5306-afdc-0cd91fb9fc3d
DOI: 10.1101/2024.01.22.576714

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