Article

Learning Human T Cell Behaviors through Generative AI Embeddings of T Cell Receptors

2025-06-22

Abstract excerpt

T cells interact with the world through T cell receptors (TCRs). The extent to which TCRs determine T cell behavior has not been comprehensively characterized. Our Tarpon model leverages advances in generative artificial intelligence to synthesize large-scale (>1M sequences) TCR atlases across human development and diseases into actionable insights. Tarpon creates: 1) bespoke sampling functions generating realisti...

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Literature Corpus work: 04bf6a7a-fe16-568e-bb78-32fdf02bfffc
DOI: 10.1101/2025.06.16.660016

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