Article
T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database.
Cell systems - 20 Aug 2025
Banerjee Amitava, Pattinson David J, Wincek Cornelia L, Bunk Paul, Axhemi Armend, Chapin Sarah R, Navlakha Saket, Meyer Hannah V
Abstract excerpt
Comprehensively mapping all targets of a T cell receptor (TCR) is important for predicting pathogenic escape and off-target effects of TCR therapies. However, this mapping has been challenging due to lack of unbiased benchmarking datasets and computational methods sensitive to small-peptide mutations. To address this, we curated the benchmark for activation of T cells with cross-reactive avidity for epitopes...
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