Article

TCR-BERT: learning the grammar of T-cell receptors for flexible antigen-xbinding analyses

2021-11-20

Abstract excerpt

The T-cell receptor (TCR) allows T-cells to recognize and respond to antigens presented by infected and diseased cells. However, due to TCRs’ staggering diversity and the complex binding dynamics underlying TCR antigen recognition, it is challenging to predict which antigens a given TCR may bind to. Here, we present TCR-BERT, a deep learning model that applies self-supervised transfer learning to this problem. TCR...

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Literature Corpus work: ef2480ba-eac2-5dce-9512-8c7dc5900aba
DOI: 10.1101/2021.11.18.469186

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