Article

A unified and self-reinforcing mechanism of tumor cell immortality

2023-05-25

Abstract excerpt

<title>Abstract</title> <p>Activating mutations in the Telomerase Reverse Transcriptase (<italic>TERT</italic>) promoter are the single most common non-coding mutation in cancer and enable limitless cell division characteristic of immortal cells<sup>1–12</sup>. Solving the immortality mechanism represents a major step towards selectively reversing it in cancer cells. <italic>TERT</italic> promoter mutations creat...

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Literature Corpus work: 99bbab2a-ecd3-5cea-9aaa-a4e8a695c014
DOI: 10.21203/rs.3.rs-2849176/v1

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