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Article

Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.

Science (New York, N.Y.) - 29 May 2015

Bell Robert J A, Rube H Tomas, Kreig Alex, Mancini Andrew, Fouse Shaun D, Nagarajan Raman P, Choi Serah, Hong Chibo, He Daniel, Pekmezci Melike, Wiencke John K, Wrensch Margaret R, Chang Susan M, Walsh Kyle M, Myong Sua, Song Jun S, Costello Joseph F

Abstract excerpt

Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, which are fundamental steps in the initiation of human cancer. Multiple cancer types, including up to 83% of glioblastomas (GBMs), harbor highly recurrent TERT...

Read the complete abstract on PubMed

Topics

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Share to Cell Line, Tumor
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Glioblastoma

Share to Promoter Regions, Genetic

Share to Protein Binding

Share to Protein Multimerization

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 25977370
DOI: 10.1126/science.aab0015
PMCID: PMC4456397

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25977370-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.PMID 25977370Read ↗

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The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible.Semantic proximity Read ↗

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TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friendsSemantic proximity Read ↗

GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer.Semantic proximity Read ↗

GABPβ1L Wakes Up TERT.Semantic proximity Read ↗

An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations.Semantic proximity Read ↗

A unified and self-reinforcing mechanism of tumor cell immortalitySemantic proximity Read ↗

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