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Article

GABPβ1L Wakes Up TERT.

Cancer cell - 10 Sept 2018

Rahme Gilbert J, Gaskell Elizabeth, Bernstein Bradley E

Abstract excerpt

TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPβ1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target.

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Identifiers

PMID: 30205042
DOI: 10.1016/j.ccell.2018.08.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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