Article
Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer.
Nature communications - 16 Sept 2022
Barger Carter J, Suwala Abigail K, Soczek Katarzyna M, Wang Albert S, Kim Min Y, Hong Chibo, Doudna Jennifer A, Chang Susan M, Phillips Joanna J, Solomon David A, Costello Joseph F
Abstract excerpt
Mutations in the TERT promoter represent the genetic underpinnings of tumor cell immortality. Beyond the two most common point mutations, which selectively recruit the ETS factor GABP to activate TERT, the significance of other variants is unknown. In seven cancer types, we identify duplications of wildtype sequence within the core promoter region of TERT that have strikingly similar features including an ETS...
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