Article
Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.
Genes & development - 1 Nov 2015
Stern Josh Lewis, Theodorescu Dan, Vogelstein Bert, Papadopoulos Nickolas, Cech Thomas R
Abstract excerpt
Somatic mutations in the promoter of the gene for telomerase reverse transcriptase (TERT) are the most common noncoding mutations in cancer. They are thought to activate telomerase, contributing to proliferative immortality, but the molecular events driving TERT activation are largely unknown. We observed in multiple cancer cell lines that mutant TERT promoters exhibit the H3K4me2/3 mark of active chromatin and...
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