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Article

GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer.

Cell reports - 20 Sept 2022

McKinney Andrew M, Mathur Radhika, Stevers Nicholas O, Molinaro Annette M, Chang Susan M, Phillips Joanna J, Costello Joseph F

Abstract excerpt

Telomerase activation counteracts senescence and telomere erosion caused by uncontrolled proliferation. Epidermal growth factor receptor (EGFR) amplification drives proliferation while telomerase reverse transcriptase promoter (TERTp) mutations underlie telomerase reactivation through recruitment of GA-binding protein (GABP). EGFR amplification and TERTp mutations typically co-occur in glioblastoma, the most...

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Identifiers

PMID: 36130485
DOI: 10.1016/j.celrep.2022.111344
PMCID: PMC9534059

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GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer.PMID 36130485Read ↗

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GABPβ1L Wakes Up TERT.Semantic proximity Read ↗

TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friendsSemantic proximity Read ↗

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A unified and self-reinforcing mechanism of tumor cell immortalitySemantic proximity Read ↗

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