Article
Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 2021
Amen Alexandra M, Fellmann Christof, Soczek Katarzyna M, Ren Shawn M, Lew Rachel J, Knott Gavin J, Park Jesslyn E, McKinney Andrew M, Mancini Andrew, Doudna Jennifer A, Costello Joseph F
Abstract excerpt
Most glioblastomas (GBMs) achieve cellular immortality by acquiring a mutation in the telomerase reverse transcriptase (TERT) promoter. TERT promoter mutations create a binding site for a GA binding protein (GABP) transcription factor complex, whose assembly at the promoter is associated with TERT reactivation and telomere maintenance. Here, we demonstrate increased binding of a specific...
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