Article
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.
Cancer cell - 10 Sept 2018
Mancini Andrew, Xavier-Magalhães Ana, Woods Wendy S, Nguyen Kien-Thiet, Amen Alexandra M, Hayes Josie L, Fellmann Christof, Gapinske Michael, McKinney Andrew M, Hong Chibo, Jones Lindsey E, Walsh Kyle M, Bell Robert J A, Doudna Jennifer A, Costa Bruno M, Song Jun S, Perez-Pinera Pablo, Costello Joseph F
Abstract excerpt
TERT promoter mutations reactivate telomerase, allowing for indefinite telomere maintenance and enabling cellular immortalization. These mutations specifically recruit the multimeric ETS factor GABP, which can form two functionally independent transcription factor species: a dimer or a tetramer. We show that genetic disruption of GABPβ1L (β1L), a tetramer-forming isoform of GABP that is dispensable for normal...
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