Article
The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible.
Molecular cell - 19 Jun 2025
Stevers Nicholas O, Kim Somang, Yuan Jimmy Bo, Barger Carter J, Hong Chibo, Lenzo Olivia, McKinney Andrew M, Wu Samuel H, Lee Yu Jin, Kwok Darwin W, Suwala Abigail K, Appin Christina L, Gordan John D, Molinaro Annette M, Song Jun S, Costello Joseph F
Abstract excerpt
Activating mutations in the telomerase reverse transcriptase (TERT) promoter are prevalent in cancer and enable limitless cell division characteristic of immortal cells. Solving the immortality mechanism represents a major step toward selective reversal in cancer cells. TERT promoter (TERTp) mutations create a de novo E26 transformation-specific (ETS) transcription factor binding motif. Here, we analyzed 53 cell...
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