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Article

TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friends

5 Aug 2020

Abstract excerpt

The transcriptional de-repression of the telomerase reverse transcriptase (TERT) gene and subsequent activation of telomerase is a prerequisite step in malignant transformation and progression. Recently, the gain-of-function mutation of the TERT promoter was identified in many types of human malignancies, and the mutated promoter acquires de novo ETS binding motifs through which the TERT transcription is...

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PMID: 32768523
DOI: 10.1016/j.canlet.2020.07.003

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