Article

Occurrence, functionality, and abundance of the <i>TERT</i> promoter mutations

2021-05-03

Abstract excerpt

Telomere shortening at chromosomal ends due to the constraints of the DNA replication process acts as a tumor suppressor by restricting the replicative potential in primary cells. Cancers evade that limitation primarily through the reactivation of telomerase via different mechanisms. Mutations within the promoter of the telomerase reverse transcriptase ( TERT ) gene represent a definite mechanism for the ribonucl...

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Literature Corpus work: 6915d405-a8f3-5246-8ae6-13ae6a7dec30
DOI: 10.1101/2021.05.03.442397

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