Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging mechanisms of telomerase reactivation in cancer.

Trends in cancer - 1 Aug 2022

Sharma Shalu, Chowdhury Shantanu

Abstract excerpt

Mutations in the promoter of human telomerase reverse transcriptase (hTERT) result in hyperactivation of hTERT. Notably, all mutations are G>A transitions, frequently found in a wide range of cancer types, and causally associated with cancer progression. Initially, the mutations were understood to reactivate hTERT by generating novel E26 transformation-specific (ETS) binding sites. Recent work reveals the role of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to Binding Sites
Share to Cancer Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Promoter Regions, Genetic

Share to Telomerase

Share to Telomeres, Telomerase, and Senescence

Source

Open in PubMed Open full text

Identifiers

PMID: 35568649
DOI: 10.1016/j.trecan.2022.03.005
PMCID: PMC7614490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging mechanisms of telomerase reactivation in cancer.PMID 35568649Read ↗

Reactivation of telomerase in cancer.Semantic proximity Read ↗

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancerSemantic proximity Read ↗

Reactivation of telomerase reverse transcriptase expression in cancer: the role of TERT promoter mutationsSemantic proximity Read ↗

Telomerase reactivation in cancers: Mechanisms that govern transcriptional activation of the wild-type vs. mutant TERT promoters.Semantic proximity Read ↗

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new playersSemantic proximity Read ↗

TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions.Semantic proximity Read ↗

Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy?Semantic proximity Read ↗

TERT gene: its function and dysregulation in cancerSemantic proximity Read ↗

Telomerase: The Devil InsideSemantic proximity Read ↗

Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in LeukemiaSemantic proximity Read ↗

The Solo Play of TERT Promoter Mutations.Semantic proximity Read ↗

Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.