Back to search

Article

Cortical thinning in temporal pole, a core region in Alzheimer’s disease, in non-demented, middle-aged <i>APOE</i> -ε4 and <i>PICALM</i> -AA/AG carriers

2025-02-25

Abstract excerpt

The symptoms of Alzheimer’s disease (AD) are caused by neurodegeneration and atrophy in particular brain regions, especially in the temporal cortex. However, the influence of genetic risk on cortical thickness in non-demented individuals prior to disease onset remains unclear. This study aimed to explore the relationship between two AD risk genes ( APOE/PICALM ) and cortical thickness in selected regions of inter...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9992155a-c0e9-5e24-a0f6-a6c8d1b357c3
DOI
10.1101/2025.02.21.639542
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Cortical thinning in temporal pole, a core region in Alzheimer’s disease, in non-demented, middle-aged <i>APOE</i> -ε4 and <i>PICALM</i> -AA/AG carriersDOI 10.1101/2025.02.21.639542
Genetic risks of Alzheimer’s by APOE and MAPT on cortical morphology in young healthy adultsSemantic proximity
Cortical structure and the risk for Alzheimer’s disease: a bidirectional Mendelian randomization studySemantic proximity
APOE4-related differences in cortical thickness are modulated by sex in middle age.Semantic proximity
The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studiesSemantic proximity
Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.Semantic proximity
Increased cortical thickness and caudate volume precede atrophy in PSEN1 mutation carriers.Semantic proximity
Association of APOE alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease neuroimaging markers.Semantic proximity
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individualsSemantic proximity
Identification of Novel Genes Associated with Cortical Thickness in Alzheimer's Disease: Systems Biology Approach to Neuroimaging Endophenotype.Semantic proximity
The effects of an APOE promoter polymorphism on human cortical morphology during nondemented aging.Semantic proximity
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals.Semantic proximity
Revealing Individual Neuroanatomical Heterogeneity in Alzheimer’s DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.