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Genetic risks of Alzheimer’s by APOE and MAPT on cortical morphology in young healthy adults

1 Jan 2023

Abstract excerpt

Abstract Genetic risk factors such as APOE ε4 and MAPT (rs242557) A allele are associated with amyloid and tau pathways and grey matter changes at both early and established stages of Alzheimer’s disease, but their effects on cortical morphology in young healthy adults remain unclear. A total of 144 participants aged from 18 to 24 underwent 3T MRI and genotyping for APOE and MAPT to investigate unique impacts of...

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PMID: 37693814
DOI: 10.1093/braincomms/fcad234

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