Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cortical structure and the risk for Alzheimer’s disease: a bidirectional Mendelian randomization study

15 Sept 2021

Abstract excerpt

Progressive loss of neurons in a specific brain area is one of the manifestations of Alzheimer's disease (AD). Much effort has been devoted to investigating brain atrophy and AD. However, the causal relationship between cortical structure and AD is not clear. We conducted a bidirectional two-sample Mendelian randomization analysis to investigate the causal relationship between cortical structure (surface area and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34526483
DOI: 10.1038/s41398-021-01599-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cortical structure and the risk for Alzheimer’s disease: a bidirectional Mendelian randomization studyPMID 34526483Read ↗

The bidirectional causal effects of brain morphology across the life course and risk of Alzheimers disease: A cross-cohort comparison and Mendelian randomization meta-analysisSemantic proximity Read ↗

Cortical thinning in temporal pole, a core region in Alzheimer’s disease, in non-demented, middle-aged <i>APOE</i> -ε4 and <i>PICALM</i> -AA/AG carriersSemantic proximity Read ↗

Inflammation and Brain Structure in Alzheimer’s Disease and Other Neurodegenerative Disorders: a Mendelian Randomization StudySemantic proximity Read ↗

Genetics impact risk of Alzheimer's disease through mechanisms modulating structural brain morphology in late life.Semantic proximity Read ↗

Brain morphology mediating the effect of genetic risk variants on Alzheimer’s diseaseSemantic proximity Read ↗

The genetic architecture of the human cerebral cortexSemantic proximity Read ↗

Causal Associations Between Imaging-derived Phenotypes and Risk of Alzheimer’s Disease and Other Neurodegenerative Disorders: A Mendelian Randomization StudySemantic proximity Read ↗

Obesity causally influencing brain cortical structure: a Mendelian randomization study.Semantic proximity Read ↗

Causal Associations Between Imaging-derived Phenotypes and Risk of Alzheimer’s Disease and Other Neurodegenerative Disorders: A Mendelian Randomization StudySemantic proximity Read ↗

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE ConsortiumSemantic proximity Read ↗

Causal relationship between cortical structural changes and onset of anxiety disorder: evidence from Mendelian randomization.Semantic proximity Read ↗

Bidirectional two-sample Mendelian randomization analyses support causal relationships between structural and diffusion imaging-derived phenotypes and the risk of major neurodegenerative diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.