The effects of an APOE promoter polymorphism on human cortical morphology during nondemented aging.

doi:10.1523/JNEUROSCI.1946-14.2015

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Article

The effects of an APOE promoter polymorphism on human cortical morphology during nondemented aging.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Jan 2015

Chen Yaojing, Li Peng, Gu Bin, Liu Zhen, Li Xin, Evans Alan C, Gong Gaolang, Zhang Zhanjun

Abstract excerpt

Apolipoprotein E (APOE) is the best-known susceptibility gene for AD. It has been well demonstrated that the ε4 allele of the APOE gene can affect brain structure/function in nondemented individuals; however, other polymorphisms in the APOE gene have been largely overlooked when assessing the effects of APOE on the neural system. Rs405509 is a newly recognized AD-related polymorphism located in the APOE promoter...

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Identifiers

PMID: 25632120
DOI: 10.1523/JNEUROSCI.1946-14.2015
PMCID: PMC6795261

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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