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Article

APOE4-related differences in cortical thickness are modulated by sex in middle age.

Brain imaging and behavior - 1 Oct 2024

Leclaire Kaitlynne N, Blujus Jenna K, Korthauer Laura E, Driscoll Ira

Abstract excerpt

Apolipoprotein E (APOE) ε4, the strongest genetic risk for late-onset Alzheimer's disease (AD), confers greater risk in females than males. While APOE4-related modulation of structural brain integrity in AD is well documented, extant literature on sex-APOE interactions has focused on older adults. The understanding of the healthy brain as a part of the normal aging process and as distinct from explicit disease or...

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PMID: 39196521
DOI: 10.1007/s11682-024-00911-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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