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Article

Association of APOE alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease neuroimaging markers.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2025

Kulminski Alexander M, Jain-Washburn Ethan, Nazarian Alireza, Wilkins Heather M, Veatch Olivia, Swerdlow Russell H, Honea Robyn A

Abstract excerpt

INTRODUCTION: TOMM40 and APOC1 variants can modulate the APOE-ε4-related Alzheimer's disease (AD) risk by up to fourfold. We aim to investigate whether the genetic modulation of ε4-related AD risk is reflected in brain morphology. METHODS: We tested whether 27 magnetic resonance imaging-derived neuroimaging markers of neurodegeneration (volume and thickness in temporo-limbic regions) are associated with...

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Source

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Identifiers

PMID: 39713891
DOI: 10.1002/alz.14445
PMCID: PMC11848341

Genes

APOE
APOC1
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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