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Article

Subtle cortical thinning in the temporal pole in middle-aged APOE-ε4 and PICALM (rs3851179) AA/AG carriers without dementia.

Neurobiology of aging - 1 Dec 2026

Dzianok Patrycja, Wojciechowski Jakub, Wolak Tomasz, Kublik Ewa

Abstract excerpt

The symptoms of Alzheimer's disease (AD) are caused by neurodegeneration and atrophy in particular brain regions, especially in the temporal lobe. However, the influence of genetic risk on cortical thickness prior to dementia onset, remains unclear. This study aimed to explore the relationship between AD genetic risk (related to APOE and PICALM genes) and cortical thickness in selected regions of interest (ROIs)...

Read the complete abstract on PubMed

Topics

Humans
Female
Male
Apolipoprotein E4
Magnetic Resonance Imaging
Monomeric Clathrin Assembly Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Alzheimer Disease

Temporal Lobe

Middle Aged

Heterozygote

Genetic Association Studies

Genetic Predisposition to Disease

Cerebral Cortical Thinning

Risk

Alleles

Source

Identifiers

PMID: 42508146
DOI: 10.1016/j.neurobiolaging.2026.07.004

Genes

APOE
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Subtle cortical thinning in the temporal pole in middle-aged APOE-ε4 and PICALM (rs3851179) AA/AG carriers without dementia.PMID 42508146Read ↗

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