Article

Protective ApoE variants support neuronal function by extracting peroxidated lipids

2025-03-10

Abstract excerpt

<h4>SUMMARY</h4> ApoE mediates the transport of lipids from neurons to glial lipid droplets. ApoE4, a major risk factor for Alzheimer’s disease, impairs this transport pathway, increasing risk for neurodegeneration. ApoE2 and ApoE3 Christchurch (ApoE3Ch) variants confer resistance to developing the disease, yet little is known regarding how these protective variants affect lipid transport. Here, we explored how l...

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Literature Corpus work: 997cfe32-0e9b-5080-9d41-6a506dd120f6
DOI: 10.1101/2025.03.05.641722

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