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Apolipoprotein E in Alzheimer’s disease: molecular insights and therapeutic opportunities

24 Apr 2025

Abstract excerpt

Apolipoprotein E (APOE- gene; apoE- protein) is the strongest genetic modulator of late-onset Alzheimer's disease (AD), with its three major isoforms conferring risk for disease ε2 < ε3 < ε4. Emerging protective gene variants, such as APOE Christchurch and the COLBOS variant of REELIN, an alternative target of certain apoE receptors, offer novel insights into resilience against AD. In recent years, the role of...

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PMID: 40275327
DOI: 10.1186/s13024-025-00843-y

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