Article

APOE3 Christchurch is associated with sphingolipids recycling and glial lipid remodeling in autosomal dominant Alzheimer’s disease

2026-07-15

Abstract excerpt

<title>Abstract</title> Alzheimer’s disease is characterized by profound disturbances in brain lipid metabolism, which regulate membrane integrity, connectivity, immune response, and cell survival. However, the mechanisms by which the protective APOE3 Christchurch variant modulates lipid homeostasis in autosomal dominant AD remain poorly understood. Here, we investigated lipid changes in postmortem brains carr...

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Literature Corpus work: 4bc9de29-1f95-5c23-a962-877280404da6
DOI: 10.21203/rs.3.rs-10297182/v1

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