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Article

T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variants

31 Aug 2023

Abstract excerpt

Pathogenic mitochondrial DNA (mtDNA) single-nucleotide variants are a common cause of adult mitochondrial disease. Levels of some variants decrease with age in blood. Given differing division rates, longevity, and energetic requirements within haematopoietic lineages, we hypothesised that cell-type-specific metabolic requirements drive this decline. We coupled cell-sorting with mtDNA sequencing to investigate...

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PMID: 37652671
DOI: 10.26508/lsa.202302271

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