Article

Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cells

2022-11-20

Abstract excerpt

Cells experience intrinsic and extrinsic pressures that affect their proclivity to expand and persist in vivo . In congenital disorders caused by loss-of-function mutations in mitochondrial DNA (mtDNA), metabolic vulnerabilities may result in cell-type specific phenotypes and depletion of pathogenic alleles, contributing to purifying selection. However, the impact of pathogenic mtDNA mutations on the cellular hem...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b8f3691-ba01-59ab-8b72-c94e3d78d733
DOI: 10.1101/2022.11.20.517242

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cellsDOI 10.1101/2022.11.20.517242Read

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.Semantic proximity Read

Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations.Semantic proximity Read

Mitochondrial variant enrichment from high-throughput single-cell RNA-seq resolves clonal populationsSemantic proximity Read

T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variantsSemantic proximity Read

A genetic bottleneck of mitochondrial DNA during human lymphocyte developmentSemantic proximity Read

T cell differentiation drives the negative selection of pathogenic mtDNA variantsSemantic proximity Read

Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humansSemantic proximity Read

Deleterious mitochondrial heteroplasmy drives high-risk clonal hematopoiesis and hematological malignancySemantic proximity Read

Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling.Semantic proximity Read

Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility.Semantic proximity Read

Mitochondrial genetics through the lens of single-cell multi-omics.Semantic proximity Read

A Genetic Bottleneck of Mitochondrial DNA During Human Lymphocyte Development.Semantic proximity Read