Article

Structural insights into mitotic-centrosome assembly

2025-10-04

Abstract excerpt

Centrosomal material assembles rapidly in mitosis. In Drosophila , the coiled-coil protein Cnn forms a scaffold that recruits PCM clients; in C.elegans , SPD-5 plays an analogous role. Here we show that full-length Cnn and SPD-5 can both form spherical condensates in vitro , but that the interactions driving their assembly into scaffolds inside cells appear to diverge. We show that the Cnn PReM adopts a helical...

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Literature Corpus work: 995ee684-1090-5ca9-818f-518a284a7690
DOI: 10.1101/2025.10.03.680336

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