Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1.

Nature communications - 30 Jun 2026

Ozaki Kanako, Chang Ting-Jui Ben, Yang Wen-Qing, Shulman Avital, Izquierdo Denisse, Jane Wann-Neng, Wang Won-Jing, Stearns Tim, Lüders Jens, Yang T Tony, Tsou Meng-Fu Bryan

Abstract excerpt

Centriole biogenesis is viewed as a template-free physical transformation where a cartwheel scaffold emerges to guide centriole growth and subsequently disassembles; however, the mechanism underlying cartwheel dynamics remains obscure. Here, we identify the intrinsically disordered protein (IDP) ALMS1 as an external cofactor that causes a seed for cartwheel formation without itself incorporating into the seed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Centrioles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CS gene

Share to HeLa Cells

Share to Intrinsically Disordered Proteins

Share to Mitosis

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42380124
DOI: 10.1038/s41467-026-74821-3
PMCID: PMC13457840

Genes

ALMS1
CS
CEP152
CEP63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1.PMID 42380124Read ↗

Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1Semantic proximity Read ↗

Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.Semantic proximity Read ↗

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and AppendagesSemantic proximity Read ↗

The <i>Caenorhabditis elegans</i> centrosome is surrounded by a membrane reticulum, the centriculum, that affects centrosome size and functionSemantic proximity Read ↗

Alström Syndrome protein Alms1 is required for maintaining meiotic centriole engagement in spermatocytes of <i>Drosophila</i>Semantic proximity Read ↗

Recent advances in pericentriolar material organization: ordered layers and scaffolding gelsSemantic proximity Read ↗

Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregationSemantic proximity Read ↗

Cep57 regulates human centrosomes through multivalent interactions.Semantic proximity Read ↗

Separation-of-function MCPH-associated mutations in CPAP affect centriole number and length.Semantic proximity Read ↗

CCDC15 localizes to the centriole inner scaffold and regulates centriole integrity and ciliogenesisSemantic proximity Read ↗

A homeostatic clock sets daughter centriole size in flies.Semantic proximity Read ↗

Atypical centrioles during sexual reproductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.