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Article

PCMD-1 stabilizes the PCM scaffold and facilitates centriole separation.

The Journal of cell biology - 1 Dec 2025

Schreiner Alina, Heim Astrid, Pletschacher Luisa, Alznauer Lisa-Marie, Schwenkert Serena, Wolff Friederike, Zanin Esther, Mikeladze-Dvali Tamara

Abstract excerpt

Centrosomes are highly dynamic organelles, and maintaining their stability is crucial for spindle pole integrity and bipolar spindle formation. Centrosomes consist of a pair of centrioles surrounded by the PCM. In Caenorhabditis elegans, interactions between the scaffold protein SPD-5 and kinase PLK-1 are essential for PCM formation. However, how PCM stability is established and maintained remains unclear. We...

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PMID: 41171095
DOI: 10.1083/jcb.202411107

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