Article

Elevated MPS1 converts the fibrous corona into a source of chromosomal instability in colon cancer

2026-08-11

Abstract excerpt

Chromosomal instability (CIN), characterised by recurrent chromosome mis-segregation, fuels intratumour heterogeneity and tumour evolution. Yet, its proximal molecular causes remain ill-defined. Tumour-scale genomic and transcriptomic analyses associate MPS1 overexpression with CIN in colon carcinomas. Consistently, CIN+ patient-derived colon cancer cells (PCCCs) display elevated MPS1, frequent merotelic kinetocho...

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Literature Corpus work: d958f520-3dd7-51d1-9fb3-f901f6af2a83
DOI: 10.64898/2026.08.07.743489

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