Article
Cep57 regulates human centrosomes through multivalent interactions.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jun 2024
Yeh Hung-Wei, Chen Po-Pang, Yeh Tzu-Chen, Lin Shiou-Lan, Chen Yue-Ting, Lin Wan-Ping, Chen Ting, Pang Jia Meng, Lin Kai-Ti, Wang Lily Hui-Ching, Lin Yu-Chun, Shih Orion, Jeng U-Ser, Hsia Kuo-Chiang, Cheng Hui-Chun
Abstract excerpt
Human Cep57 is a coiled-coil scaffold at the pericentriolar matrix (PCM), controlling centriole duplication and centrosome maturation for faithful cell division. Genetic truncation mutations of Cep57 are associated with the mosaic-variegated aneuploidy (MVA) syndrome. During interphase, Cep57 forms a complex with Cep63 and Cep152, serving as regulators for centrosome maturation. However, the molecular interplay...
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