Article

Auto-inhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects

2020-10-05

Abstract excerpt

γ-tubulin ring complexes (γ-TuRCs) nucleate microtubules. They are recruited to centrosomes in dividing cells via binding to N-terminal CM1 domains within γ-TuRC-tethering proteins, including Drosophila Cnn. Binding promotes microtubule nucleation and is restricted to centrosomes in dividing cells, but the mechanism regulating binding remains unknown. Here we identify an extreme N-terminal “CM1 auto-inhibition” (...

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Literature Corpus work: e9193305-acbe-5b78-a77d-6548cc54eb4f
DOI: 10.1101/2020.10.05.326587

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