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Article

HERD-1 mediates multiphase condensate immiscibility to regulate small RNA-driven transgenerational epigenetic inheritance.

Nature cell biology - 1 Nov 2024

Zhao Changfeng, Cai Shiyu, Shi Ruona, Li Xinru, Deng Boyuan, Li Ruofei, Yang Shuhan, Huang Jing, Liang Yonglin, Lu Pu, Yuan Zhongping, Jia Haoxiang, Jiang Zongjin, Zhang Xiaofei, Kennedy Scott, Wan Gang

Abstract excerpt

Biomolecular condensates, such as the nucleolus, stress granules/processing bodies and germ granules, are multiphase assemblages whose formation mechanisms and significance remain poorly understood. Here we identify protein constituents of the spatiotemporally ordered P, Z and M multiphase condensates in Caenorhabditis elegans germ granules using optimized TurboID-mediated proximity biotin labelling. These...

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PMID: 39354132
DOI: 10.1038/s41556-024-01514-8

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