An expansive human regulatory lexicon encoded in transcription factor footprints.

doi:10.1038/nature11212

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Article

An expansive human regulatory lexicon encoded in transcription factor footprints.

Nature - 6 Sept 2012

Neph Shane, Vierstra Jeff, Stergachis Andrew B, Reynolds Alex P, Haugen Eric, Vernot Benjamin, Thurman Robert E, John Sam, Sandstrom Richard, Johnson Audra K, Maurano Matthew T, Humbert Richard, Rynes Eric, Wang Hao, Vong Shinny, Lee Kristen, Bates Daniel, Diegel Morgan, Roach Vaughn, Dunn Douglas, Neri Jun, Schafer Anthony, Hansen R Scott, Kutyavin Tanya, Giste Erika, Weaver Molly, Canfield Theresa, Sabo Peter, Zhang Miaohua, Balasundaram Gayathri, Byron Rachel, MacCoss Michael J, Akey Joshua M, Bender M A, Groudine Mark, Kaul Rajinder, Stamatoyannopoulos John A

Abstract excerpt

Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting across 41 diverse cell and tissue types, we detected 45 million transcription factor occupancy events within regulatory regions, representing differential binding to 8.4 million distinct short sequence elements. Here we show that this...

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Identifiers

PMID: 22955618
DOI: 10.1038/nature11212
PMCID: PMC3736582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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