Article

Overlapping binding sites underlie TF genomic occupancy

2024-03-06

Abstract excerpt

Sequence-specific DNA binding by transcription factors (TFs) is a crucial step in gene regulation. However, current high-throughput in vitro approaches cannot reliably detect lower affinity TF-DNA interactions, which play key roles in gene regulation. Here, we developed PADIT-seq ( p rotein a ffinity to D NA by in vitro transcription and RNA seq uencing) to assay TF binding preferences to all 10-bp DNA seque...

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Literature Corpus work: 6d8bc41f-34ef-5fff-b56e-bc8e8a767a74
DOI: 10.1101/2024.03.05.583629

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