Article

Missense variants in human forkhead transcription factors reveal determinants of forkhead DNA bispecificity

2025-05-30

Abstract excerpt

<h4>Summary</h4> Recognition of specific DNA sequences by transcription factors (TFs) is a key step in transcriptional control of gene expression. While most forkhead (FH) TFs bind either an FKH (RYAAAYA) or an FHL (GACGC) recognition motif, some FHs can bind both motifs. Mechanisms that control whether a FH is monospecific versus bispecific have remained unknown. Screening a library of 12 reference FH proteins,...

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Literature Corpus work: b06c21a0-3def-56d2-8e7c-a2e93b113418
DOI: 10.1101/2025.05.27.656303

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