Article
Survey of variation in human transcription factors reveals prevalent DNA binding changes.
Science (New York, N.Y.) - 25 Mar 2016
Barrera Luis A, Vedenko Anastasia, Kurland Jesse V, Rogers Julia M, Gisselbrecht Stephen S, Rossin Elizabeth J, Woodard Jaie, Mariani Luca, Kock Kian Hong, Inukai Sachi, Siggers Trevor, Shokri Leila, Gordân Raluca, Sahni Nidhi, Cotsapas Chris, Hao Tong, Yi Song, Kellis Manolis, Daly Mark J, Vidal Marc, Hill David E, Bulyk Martha L
Abstract excerpt
Sequencing of exomes and genomes has revealed abundant genetic variation affecting the coding sequences of human transcription factors (TFs), but the consequences of such variation remain largely unexplored. We developed a computational, structure-based approach to evaluate TF variants for their impact on DNA binding activity and used universal protein-binding microarrays to assay sequence-specific DNA binding...
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