Article

Discovery of Primary, Cofactor, and Novel Transcription Factor Binding Site Motifs by Recursive, Thresholded Entropy Minimization

2016-03-09

Abstract excerpt

<h4>ABSTRACT</h4> Data from ChIP-seq experiments can determine the genome-wide binding specificities of transcription factors (TFs) and other regulatory proteins. In the present study, we analyzed 745 ENCODE ChIP-seq peak datasets of 189 human TFs with a novel motif discovery method that is based on recursive, thresholded entropy minimization. This method is able to distinguish correct information models from noi...

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Literature Corpus work: 59b70b68-c9a3-5bca-8751-3ba4f2592715
DOI: 10.1101/042853

Open publication

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