Article

Intrinsic specificity differences between transcription factor paralogs partly explain their differential in vivo binding

2017-10-25

Abstract excerpt

<h4>ABSTRACT</h4> Members of transcription factor (TF) families, i.e. paralogous TFs, are oftentimes reported to have identical DNA-binding motifs, despite the fact that they perform distinct regulatory functions in the cell. Differential genomic targeting by paralogous TFs is generally assumed to be due to interactions with protein cofactors or the chromatin environment. Contrary to previous assumptions, we find...

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Literature Corpus work: b173213e-563b-5ff5-a73d-d23a1df31d54
DOI: 10.1101/208561

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