Article

From motif to function: Inferring the functions of long zinc finger proteins through combinatorial selection

2022-04-20

Abstract excerpt

<h4>ABSTRACT</h4> C2H2 zinc finger proteins (ZFPs) comprise of the largest group of DNA-binding proteins in human genome, and many of them contain long, tandem array of fingers, making the motif discovery, prediction of in vivo cis -regulatory elements (CREs), and understanding their functions particularly challenging. Previous work established that due to the dependent recognition between sub-motifs, the simple...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c545fb38-d3d8-577f-97bb-9ed785603867
DOI: 10.1101/2022.04.19.488842

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

From motif to function: Inferring the functions of long zinc finger proteins through combinatorial selectionDOI 10.1101/2022.04.19.488842Read

Quantitative analysis of ZFY and CTCF reveals dependent recognition of tandem zinc finger proteinsSemantic proximity Read

GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factorsSemantic proximity Read

Integrative analysis reveals extensive interactions among C2H2 zinc finger proteins at chromatin loop anchorsSemantic proximity Read

ZNF423 orthologs are highly constrained in vertebrates but show domain-level plasticity across invertebrate lineagesSemantic proximity Read

A domain-resolution map of <i>in vivo</i> DNA binding reveals the regulatory consequences of somatic mutations in zinc finger transcription factorsSemantic proximity Read

Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.Semantic proximity Read

Factorbook: an Updated Catalog of Transcription Factor Motifs and Candidate Regulatory Motif SitesSemantic proximity Read

A map of direct TF-DNA interactions in the human genomeSemantic proximity Read

Codebook: sequence specificity and genomic binding of poorly-characterized human transcription factorsSemantic proximity Read

Discovery of Primary, Cofactor, and Novel Transcription Factor Binding Site Motifs by Recursive, Thresholded Entropy MinimizationSemantic proximity Read

MOCCS profile analysis clarifies the cell type dependency of transcription factor-binding sequences and cis-regulatory SNPs in humansSemantic proximity Read

Identification of methylation-sensitive human transcription factors using meSMiLE-seqSemantic proximity Read