Article

Functional role of fatty acid synthase for signal transduction in Core binding factor-AML with activating c-Kit mutation

2024-08-05

Abstract excerpt

<title>Abstract</title> <p>Background AML is a rare hematological malignancy still associated with poor prognosis. 5% of de novo AML and 30% of core binding factor (CBF) AML (translocation t(8;21)(q22;q22) or invasion (16)(p13;q22)), respectively, harbor activating c-Kit (CD117) mutations leading to an adverse clinical outcome. Posttranslational protein modifications, especially by myristolic and palmitic acid,...

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Literature Corpus work: 99385194-f137-5b23-845a-a67304478c6a
DOI: 10.21203/rs.3.rs-4648786/v1

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