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Article

Molecular Pathways: Fatty Acid Synthase

31 Oct 2015

Abstract excerpt

Therapies that target tumor metabolism represent a new horizon in anticancer therapies. In particular, cancer cells are dependent on the generation of lipids, which are essential for cell membrane synthesis, modification of proteins, and localization of many oncogenic signal transduction enzymes. Because fatty acids are the building blocks of these important lipids, fatty acid synthase (FASN) emerges as a unique...

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PMID: 26519059
DOI: 10.1158/1078-0432.ccr-15-0126

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